5-Amino-1MQ: A Research Overview of the NNMT Inhibitor
All information here is for laboratory and educational research only. No compound referenced is approved for human or veterinary use, and nothing here is medical advice.
- 5-Amino-1MQ is a small molecule (not a peptide) studied in metabolic research because it blocks an enzyme called NNMT, which is linked to NAD plus, a chemical cells use for energy.
- The research is early and almost entirely in cells and animals. In mouse studies, compounds of this type reduced obesity caused by a high-fat diet, but these results have not been tested in people.
- There are no published human trials, so there is no controlled human safety or effectiveness data. Online community reports about fat loss are personal anecdotes, not measured results.
- It is not approved by the FDA for any use and is not an approved drug, supplement, or food ingredient.
- BioRegen does not claim it works and sells it strictly for laboratory and educational research, not for human or veterinary use.
5-Amino-1MQ is a small molecule that scientists have started paying more attention to in metabolic research. It works by blocking an enzyme called NNMT (short for nicotinamide N-methyltransferase). An enzyme is just a protein that speeds up a chemical reaction in the body. This page explains, in plain terms, what blocking NNMT means, what published studies have looked at, and how researchers handle 5-Amino-1MQ in the lab. This information is for laboratory and educational purposes only. 5-Amino-1MQ is not approved for human or veterinary use.
What is NNMT, and why does it matter?
NNMT is an enzyme that helps the body process a vitamin building block called nicotinamide. Nicotinamide is one of the ingredients cells use to make NAD+, a molecule that helps cells turn food into energy. In published studies, when NNMT is very active, researchers have seen changes in how cells handle energy in their test models. So scientists study what happens when you slow NNMT down: it may change how much NAD+ is available and how cells send energy-related signals. That is the main reason researchers are interested in 5-Amino-1MQ.
What the research explores
Early research on 5-Amino-1MQ has looked at how it affects fat cells (the cells that store fat), how cells use energy, and NAD+ levels. This work has been done in animals and in cells, not in people. As with many newer research molecules, the science is still early and mostly done in the lab. So the results point in a direction worth studying, but they are not proof of anything yet.
How it differs from peptides
Most products discussed on this site are peptides, which are short chains of amino acids. 5-Amino-1MQ is different. It is a small molecule, not a peptide. That changes how researchers handle and store it in the lab. It also means it sits alongside, but is not the same as, the metabolic and repair peptides that researchers often work with.
Frequently asked questions
Is 5-Amino-1MQ a peptide?
No. It is a small molecule that blocks the NNMT enzyme. It is not a peptide. That said, researchers often study it in the same metabolic research projects as peptides.
What is the connection to NAD+?
Cells have a recycling route that helps them rebuild their NAD+ supply, sometimes called the NAD+ salvage pathway. Research suggests that by slowing down NNMT, 5-Amino-1MQ may affect that recycling route. Since NAD+ is so important for how cells make energy, this is an active area of study.
Explore related compounds in our metabolic research (BURN) collection or the full research catalog.
Selected research references
- Neelakantan H, et al. Selective and membrane-permeable small molecule inhibitors of nicotinamide N-methyltransferase reverse high fat diet-induced obesity in mice. Biochem Pharmacol. 2018. doi:10.1016/j.bcp.2017.11.007
- Kraus D, et al. Nicotinamide N-methyltransferase knockdown protects against diet-induced obesity. Nature. 2014. doi:10.1038/nature13198
Reference metadata sourced via PubMed.
Disclaimer: All products and information provided by BioRegen are for laboratory and educational research purposes only. Nothing here is medical advice, and 5-Amino-1MQ is not approved for human or veterinary use.